Seriolo B, Cutolo M, De Cesari F, Accardo S
DIMI, Cattedra di Reumatologia, Genova.
Medicina (Firenze). 1990 Oct-Dec;10(4):401-2.
Metalloproteinases (e.g. collagenase, elastase, stromelysin) are present in large amount in synovial fluid (SF) during rheumatoid arthritis (RA) and are actively involved in articular tissue damage. alpha 2-Macroglobulin (alpha 2M) functions as a "molecular trap" for proteinases and is considered the major inhibitor of metalloproteinases. We found increased concentrations of alpha 2M in SF of RA patients, significantly related to acute phase reactants, local inflammatory parameters and joint damage. The alpha 2M ratio between, RA SF and control SF, was found higher than between RA serum and control serum, indicating a selective localization and activity of alpha 2M in inflamed joint. The relationship between alpha 2M and the inflammatory parameters, including IL-6, is discussed.
金属蛋白酶（如胶原酶、弹性蛋白酶、基质溶解素）在类风湿性关节炎（RA）期间大量存在于滑液（SF）中，并积极参与关节组织损伤。α2巨球蛋白（α2M）作为蛋白酶的“分子陷阱”，被认为是金属蛋白酶的主要抑制剂。我们发现RA患者滑液中α2M浓度升高，与急性期反应物、局部炎症参数和关节损伤显著相关。发现RA滑液与对照滑液之间的α2M比值高于RA血清与对照血清之间的比值，表明α2M在炎症关节中具有选择性定位和活性。讨论了α2M与包括IL-6在内的炎症参数之间的关系。
