Elwassif Maged M, Kong Qingjun, Vazquez Maribel, Bikson Marom
Department of Biomedical Engineering, The City College of New York of The City University of New York, NY 10031, USA.
J Neural Eng. 2006 Dec;3(4):306-15. doi: 10.1088/1741-2560/3/4/008. Epub 2006 Nov 6.
There is a growing interest in the use of chronic deep brain stimulation (DBS) for the treatment of medically refractory movement disorders and other neurological and psychiatric conditions. Fundamental questions remain about the physiologic effects of DBS. Previous basic research studies have focused on the direct polarization of neuronal membranes by electrical stimulation. The goal of this paper is to provide information on the thermal effects of DBS using finite element models to investigate the magnitude and spatial distribution of DBS-induced temperature changes. The parameters investigated include stimulation waveform, lead selection, brain tissue electrical and thermal conductivities, blood perfusion, metabolic heat generation during the stimulation and lead thermal conductivity/heat dissipation through the electrode. Our results show that clinical DBS protocols will increase the temperature of surrounding tissue by up to 0.8 degrees C depending on stimulation/tissue parameters.
对于使用慢性深部脑刺激（DBS）治疗药物难治性运动障碍以及其他神经和精神疾病的兴趣与日俱增。关于DBS的生理效应仍存在一些基本问题。以往的基础研究主要集中在电刺激对神经元膜的直接极化作用上。本文的目的是利用有限元模型提供有关DBS热效应的信息，以研究DBS引起的温度变化的幅度和空间分布。所研究的参数包括刺激波形、电极选择、脑组织的电导率和热导率、血液灌注、刺激过程中的代谢产热以及电极的热导率/通过电极的散热情况。我们的结果表明，根据刺激/组织参数，临床DBS方案会使周围组织的温度升高多达0.8摄氏度。
