Bonecchi Raffaella, Borroni Elena M, Savino Benedetta, Buracchi Chiara, Mantovani Alberto, Locati Massimo
Istituto Clinico Humanitas, IRCCS Via Manzoni 113, I-20089 Rozzano, Milan, Italy.
J Neuroimmunol. 2008 Jul 31;198(1-2):14-9. doi: 10.1016/j.jneuroim.2008.04.018. Epub 2008 Jun 2.
Cell migration is fundamental for numerous biological processes and is critical for the pathogenesis of several diseases. Chemokines represent the main class of mediators providing cell directional migration and several levels of regulation of their function have been identified. A subfamily of chemokine receptors not able to transduce chemotactic signals plays an important role in the control of chemokine concentrations through binding, internalization and degradation of chemotactic factors. Here we review in vitro and in vivo evidences indicating that these 'silent' chemokine receptors represent a strategy to regulate innate and adaptive immunity.
细胞迁移是众多生物学过程的基础，对多种疾病的发病机制至关重要。趋化因子是提供细胞定向迁移的主要一类介质，并且已经确定了其功能的多个调控水平。一类无法转导趋化信号的趋化因子受体亚家族，通过趋化因子的结合、内化和降解，在控制趋化因子浓度方面发挥重要作用。在此，我们综述了体外和体内的证据，表明这些“沉默”的趋化因子受体是调节先天性免疫和适应性免疫的一种策略。
