Borroni E M, Buracchi C, de la Torre Y Martinez, Galliera E, Vecchi A, Bonecchi R, Mantovani A, Locati M
Istituto Clinico Humanitas, Via Manzoni 56, I-20089 Rozzano, Milan, Italy.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1014-7. doi: 10.1042/BST0341014.
Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.
除了在炎症反应中维持白细胞募集的信号受体外，趋化因子系统还包括具有独特特异性和组织分布的“沉默”受体。该亚组中最具特征的分子是CC趋化因子受体D6，它能结合大多数炎性CC趋化因子，并通过组成型非配体依赖性内化将它们靶向降解。结构功能分析和基因靶向动物的最新研究结果表明，D6具有独特的功能和结构特征，使其非常适合作为趋化因子诱饵和清除受体，战略性地定位在淋巴管内皮和胎盘上，以减轻组织和引流淋巴结中的炎症。
