Dobrogosz W J, Hall G W, Sherba D K, Silva D O, Harman J G, Melton T
Mol Gen Genet. 1983;192(3):477-86. doi: 10.1007/BF00392194.
A well-characterized set of pts deletion mutants of Salmonella typhimurium were used to re-evaluate the purported role of the PTS in the inducer exclusion process and in regulation cAMP synthesis. During the course of these studies a class of secondary mutations was isolated which suppress the inhibition of cAMP synthesis caused by pts mutations. These suppressor mutations were traced to the crp locus and tentatively designated as acr (adenylate cyclase regulation) mutations. A new model is proposed in which CRP rather than adenylate cyclase is believed to be the central regulatory element in the catabolite repression phenomenon.
利用一组特征明确的鼠伤寒沙门氏菌pts缺失突变体，重新评估磷酸转移酶系统（PTS）在诱导物排除过程及环磷酸腺苷（cAMP）合成调控中所声称的作用。在这些研究过程中，分离出一类二次突变，其可抑制由pts突变引起的cAMP合成抑制。这些抑制突变被追溯至crp基因座，并暂时命名为acr（腺苷酸环化酶调节）突变。提出了一种新模型，其中CRP而非腺苷酸环化酶被认为是分解代谢物阻遏现象中的核心调节元件。
