对氟喹诺酮类高度耐药的无乳链球菌
[Streptococcus agalactiae highly resistant to fluoroquinolones].
作者信息
Miró Elisenda, Rebollo Montserrat, Rivera Alba, Alvarez M Teresa, Navarro Ferrán, Mirelis Beatriz, Coll Pere
机构信息
Servicio de Microbiología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
出版信息
Enferm Infecc Microbiol Clin. 2006 Nov;24(9):562-3. doi: 10.1157/13093876.
BACKGROUND
Streptococcus agalactiae remains susceptible to penicillin; nevertheless, an increase in the resistance to other antimicrobial families, such as macrolides and more rarely fluoroquinolones, has been described.
METHODS AND RESULTS
From 2003 to 2004, two fluoroquinolone-resistant S. agalactiae strains were detected. The strains presented one mutation in parC (Ser79 --> Phe) and an additional mutation in gyrA (Glu85 --> Ala or Glu85 --> Lys).
CONCLUSION
This study describes the first S. agalactiae strains highly resistant to fluoroquinolones in Spain.
背景
无乳链球菌对青霉素仍敏感；然而，已有报道称其对其他抗菌药物类别（如大环内酯类，较少见的氟喹诺酮类）的耐药性有所增加。
方法与结果
2003年至2004年，检测到两株耐氟喹诺酮类的无乳链球菌菌株。这些菌株在parC基因发生一个突变（Ser79 --> Phe），在gyrA基因发生另一个突变（Glu85 --> Ala或Glu85 --> Lys）。
结论
本研究描述了西班牙首例对氟喹诺酮类高度耐药的无乳链球菌菌株。
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