耐氟喹诺酮类无乳链球菌：流行病学及耐药机制
Fluoroquinolone-resistant Streptococcus agalactiae: epidemiology and mechanism of resistance.
作者信息
Wehbeh Wehbeh, Rojas-Diaz Roberto, Li Xinying, Mariano Noriel, Grenner Louise, Segal-Maurer Sorana, Tommasulo Barbara, Drlica Karl, Urban Carl, Rahal James J
机构信息
Infectious Disease Section, Department of Medicine and Lang Research Center, New York Hospital Queens, 56-45 Main Street, Flushing, NY 11355, USA.
出版信息
Antimicrob Agents Chemother. 2005 Jun;49(6):2495-7. doi: 10.1128/AAC.49.6.2495-2497.2005.
Abstract
Quinolone-resistant Streptococcus agalactiae bacteria were recovered from single-patient isolates and found to contain mutations in the gyrase and topoisomerase IV genes. Pulsed-field gel electrophoresis demonstrated that four isolates from the same long-term care facility were closely related; in seven cases, quinolone-resistant Haemophilus influenzae and S. agalactiae bacteria were isolated from the same patient.
摘要
耐喹诺酮的无乳链球菌从单患者分离株中分离得到，并发现其gyrase和拓扑异构酶IV基因存在突变。脉冲场凝胶电泳显示，来自同一长期护理机构的4株分离株密切相关；在7例病例中，耐喹诺酮的流感嗜血杆菌和无乳链球菌从同一患者体内分离得到。
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