Wilflingseder Doris, Stoiber Heribert
Department of Hygiene, Medical Microbiology and Social Medicine, Innsbruck Medical University, Fritz-Preglstr.3, 6020 Innsbruck, Austria.
Front Biosci. 2007 Jan 1;12:2124-35. doi: 10.2741/2216.
All steps in the HIV lifecycle--entry, assembly, budding, induction of signal transduction and subsequent cell activation--are complex multifactorial mechanisms where cholesterol and sphingolipids (glycosphingolipids--GSLs and sphingomyelins in mammalian cells) are closely involved. Here we will review the contribution of these heterogeneous membrane lipid microdomains, referred to as lipid rafts, DIGs (detergent-insoluble glycolipid-enriched complexes), DRMs (detergent-resistant membranes), GEMs (glycolipid-enriched membranes), caveolae, TIMs (Triton-insoluble membranes) for interactions of HIV with the host cell. The accurate terminology was discussed elsewhere, and to simplify matters we will use rafts or lipid rafts throughout the review.
HIV生命周期中的所有步骤——进入、组装、出芽、信号转导诱导及随后的细胞激活——都是复杂的多因素机制，其中胆固醇和鞘脂（哺乳动物细胞中的糖鞘脂——GSLs和鞘磷脂）密切参与其中。在此，我们将综述这些异质性膜脂微结构域，即脂筏、DIGs（去污剂不溶性富含糖脂的复合物）、DRMs（去污剂抗性膜）、GEMs（富含糖脂的膜）、小窝、TIMs（曲拉通不溶性膜）在HIV与宿主细胞相互作用中的作用。准确的术语在其他地方已有讨论，为简化起见，我们在整个综述中将使用脂筏或脂质筏。
