Chakraborti Amitabha, Lodha Rakesh, Pandey R M, Kabra S K
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Indian J Pediatr. 2006 Nov;73(11):979-83. doi: 10.1007/BF02758300.
To evaluate effect of addition of ipratropium to salbutamol delivered by metered dose inhaler and spacer in the beginning of treatment of mild to moderate exacerbation of asthma.
Children between 5 to 15 years of age with mild to moderate exacerbation of asthma were randomized to receive either a combination of ipratropium bromide and salbutamol or salbutamol alone administered by metered dose inhaler and spacer. The effects on clinical asthma score and spirometric parameters were compared.
A total of 60 children were randomized in the study. The baseline characteristics of two groups were comparable. Children getting combination of salbutamol and ipratropium showed significantly greater improvement in percent-predicted PEFR and FEF25-75% than children receiving salbutamol alone.
There was beneficial effect of addition of ipratropium to salbutamol administered by MDI with spacer at the beginning of therapy for mild to moderate acute exacerbation of asthma in children.
评估在轻至中度哮喘急性加重期治疗开始时，在使用定量吸入器和储物罐吸入沙丁胺醇的基础上加用异丙托溴铵的效果。
将5至15岁轻至中度哮喘急性加重期的儿童随机分组，分别接受异丙托溴铵与沙丁胺醇联合制剂或单用沙丁胺醇治疗，均通过定量吸入器和储物罐给药。比较两组对临床哮喘评分和肺功能参数的影响。
本研究共纳入60例随机分组的儿童。两组的基线特征具有可比性。联合使用沙丁胺醇和异丙托溴铵的儿童，其预计值百分比的呼气峰流速（PEFR）和25%~75%用力呼气流量（FEF25-75%）的改善程度显著大于单用沙丁胺醇的儿童。
在儿童轻至中度哮喘急性加重期治疗开始时，使用定量吸入器和储物罐吸入沙丁胺醇的基础上加用异丙托溴铵有有益作用。
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