Heikinheimo K, Persson S, Kindblom L G, Morgan P R, Virtanen I
Department of Pathology, University of Helsinki, Finland.
J Pathol. 1991 Jun;164(2):145-50. doi: 10.1002/path.1711640208.
A detailed immunohistochemical characterization of different cytokeratin subclasses was performed on frozen tumour tissue from three classical chordomas. Simple epithelium cytokeratins Nos 8, 18, and 19 were detected in all tumour cells while cytokeratin No. 7 was not found. Cytokeratins characteristic of squamous differentiation, including keratinization, were generally lacking, with the exception of the varying expression of cytokeratin No. 4. Vimentin was found in all the tumours, while they lacked desmin immunoreactivity. The present study indicates the co-expression of vimentin and cytokeratins, predominantly of the simple epithelium type. In addition, chordoma cells have the ability to express cytokeratins characteristic of squamous differentiation. This finding corresponds well to the electron microscopic findings of tonofilament bundles ending in well-developed desmosomes.
对来自三个典型脊索瘤的冰冻肿瘤组织进行了不同细胞角蛋白亚类的详细免疫组织化学特征分析。在所有肿瘤细胞中均检测到简单上皮细胞角蛋白8、18和19，而未发现细胞角蛋白7。除细胞角蛋白4的不同表达外，通常缺乏鳞状分化特征性的细胞角蛋白，包括角化。在所有肿瘤中均发现波形蛋白，而它们缺乏结蛋白免疫反应性。本研究表明波形蛋白和细胞角蛋白共表达，主要是简单上皮类型。此外，脊索瘤细胞有能力表达鳞状分化特征性的细胞角蛋白。这一发现与电镜下张力丝束末端形成发达桥粒的结果非常吻合。
