内质网靶向信号：不止表面所见？

ER targeting signals: more than meets the eye?

作者信息

Swanton Eileithyia, High Stephen

机构信息

Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK.

出版信息

Cell. 2006 Dec 1;127(5):877-9. doi: 10.1016/j.cell.2006.11.018.

DOI:10.1016/j.cell.2006.11.018

PMID:17129773

Abstract

The signal sequences that target newly synthesized proteins to the endoplasmic reticulum are highly variable; however, the functional significance of this diversity has remained obscure. In this issue, Kang et al. (2006) report that variability in signal sequences allows the cell to selectively regulate the translocation of proteins into the endoplasmic reticulum in a substrate-specific manner.

摘要

将新合成的蛋白质靶向内质网的信号序列高度可变；然而，这种多样性的功能意义仍不清楚。在本期中，Kang等人（2006年）报告称，信号序列的变异性使细胞能够以底物特异性方式选择性地调节蛋白质向内质网的转运。