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The development of rational strategies for selective immunotherapy against autoimmune demyelinating disease.

作者信息

Steinman L

机构信息

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California 94305.

出版信息

Adv Immunol. 1991;49:357-79. doi: 10.1016/s0065-2776(08)60779-8.

DOI:10.1016/s0065-2776(08)60779-8
PMID:1713016
Abstract
摘要

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Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis.腺相关病毒介导的过氧化氢酶表达可抑制实验性变应性脑脊髓炎中的视神经炎。
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Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use.
治疗用混合正常免疫球蛋白中存在针对HLA I类分子保守区域的抗体,这些抗体能够调节CD8 T细胞介导的功能。
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Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.髓鞘碱性蛋白表位的可溶性肽变体对实验性自身免疫性脑脊髓炎的逆转作用:T细胞受体拮抗及γ干扰素和肿瘤坏死因子α生成的减少
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