博尔纳病病毒特异性T细胞可预防或引发免疫病理性博尔纳病。
Borna disease virus-specific T cells protect against or cause immunopathological Borna disease.
作者信息
Richt J A, Schmeel A, Frese K, Carbone K M, Narayan O, Rott R
机构信息
Institut für Virologie, Giessen, Germany.
出版信息
J Exp Med. 1994 May 1;179(5):1467-73. doi: 10.1084/jem.179.5.1467.
Abstract
In this report we show that passive immunization of Lewis rats with viable CD4+, Borna disease virus (BDV)-specific T cells before infection with BDV resulted in protection against BD, whereas inoculation of these T cells after BDV infection induced clinical disease with more rapid onset than seen in BDV control animals. The protective as well as encephalitogenic effector functions of BDV-specific CD4+ T cells were mediated only by viable BDV-specific T cells. The protective situation was obtained by passive transfer of BDV-specific T cells into animals inoculated later with virus, whereas the immunopathological situation was observed when virus-specific T cells developed normally or after adoptive transfer, and appeared on the scene after considerable virus replication in the brain.
摘要
在本报告中，我们表明，在感染博尔纳病病毒（BDV）之前，用活的CD4⁺、BDV特异性T细胞对Lewis大鼠进行被动免疫可使其免受BD侵害，而在BDV感染后接种这些T细胞则会引发临床疾病，且发病比BDV对照动物更快。BDV特异性CD4⁺T细胞的保护性功能以及致脑炎性效应功能仅由活的BDV特异性T细胞介导。通过将BDV特异性T细胞被动转移到后来接种病毒的动物体内可实现保护状态，而当病毒特异性T细胞正常发育或经过继转移后，且在大脑中大量病毒复制后才出现时，则会观察到免疫病理状态。
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