Chapkin Robert S, McMurray David N, Lupton Joanne R
Faculty of Nutrition, Texas A & M University System Health Science Center, College Station, Texas 77843, USA.
Curr Opin Gastroenterol. 2007 Jan;23(1):48-54. doi: 10.1097/MOG.0b013e32801145d7.
To outline recent findings on the efficacy of n-3 polyunsaturated fatty acids in the prevention/treatment of inflammatory bowel disease and colorectal cancer.
Compelling data indicate a functional link between chronic inflammation and colon cancer. With respect to environmental risk factors, there is growing evidence that long-chain n-3 polyunsaturated fatty acids found in fish oil suppress inflammatory bowel diseases and colon cancer risk in humans. Unfortunately, the molecular basis of the effect of n-3 polyunsaturated fatty acids on inflammation/colitis-associated colon cancer risk is still largely obscure. In this review, we focus on recent studies which address three emerging mechanisms of n-3 polyunsaturated fatty acids action: (1) metabolic interconversion into bioactive eicosanoids, (2) modulation of nuclear receptor activation, and (3) alteration of membrane phospholipid composition and functionality of lipid microdomains.
The consumption of dietary fish oil may prove to be an effective adjuvant therapy in colon cancer. Therefore, it is both appropriate and timely to determine precisely how n-3 polyunsaturated fatty acids modulate cell signaling networks, and reduce the risk of developing colon cancer and inflammatory disorders of the intestine.
概述n-3多不饱和脂肪酸在预防/治疗炎症性肠病和结直肠癌方面的最新疗效研究结果。
有力数据表明慢性炎症与结肠癌之间存在功能联系。关于环境风险因素，越来越多的证据表明鱼油中含有的长链n-3多不饱和脂肪酸可抑制人类的炎症性肠病和结肠癌风险。遗憾的是，n-3多不饱和脂肪酸对炎症/结肠炎相关结肠癌风险影响的分子基础仍大多不明。在本综述中，我们重点关注近期研究，这些研究探讨了n-3多不饱和脂肪酸作用的三种新出现机制：（1）代谢转化为生物活性类二十烷酸，（2）调节核受体激活，以及（3）改变膜磷脂组成和脂质微区的功能。
食用膳食鱼油可能被证明是结肠癌的一种有效辅助治疗方法。因此，准确确定n-3多不饱和脂肪酸如何调节细胞信号网络以及降低患结肠癌和肠道炎症性疾病的风险既恰当又及时。
