Krari N, Allain P
Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.
Biol Trace Elem Res. 1991 May;29(2):125-31. doi: 10.1007/BF03032689.
Ethylene diamine tetraacetic acid (EDTA), nitrilotriacetic acid (NTA), and tripolyphosphate (TPP) sodium salts were given orally to rats at the dose of 1 mmol/kg/d for 35 d. The concentrations of Na, K, Ca, Mg, P, S, Fe, Sr, Cu, and Zn were determined in blood, plasma, brain, heart, muscle, liver, kidney, duodenum, and bone of control rats and of the rats receiving EDTA, NTA, and TPP. The main effect induced by EDTA, NTA, and TPP was a decrease of the concentrations of several elements Ca, Mg, Fe, P in the duodenum. Otherwise, EDTA induced an increase of Zn in the kidney (+ 20%), NTA, an increase of Fe in liver (+ 29%), and particularly an increase of Zn in bone (+ 44%). TPP induced a slight decrease of Zn and Cu in liver. In conclusion, EDTA, NTA, and TPP taken orally at the dose of 1 mmol/kg/d for 35 d induced moderate changes of the concentrations of some elements in rat tissues, but without signs of toxicity.
将乙二胺四乙酸（EDTA）、次氮基三乙酸（NTA）和三聚磷酸钠（TPP）以1 mmol/kg/d的剂量口服给予大鼠，持续35天。测定了对照大鼠以及接受EDTA、NTA和TPP的大鼠的血液、血浆、脑、心脏、肌肉、肝脏、肾脏、十二指肠和骨骼中钠、钾、钙、镁、磷、硫、铁、锶、铜和锌的浓度。EDTA、NTA和TPP的主要作用是使十二指肠中几种元素（钙、镁、铁、磷）的浓度降低。此外，EDTA使肾脏中的锌含量增加（+20%），NTA使肝脏中的铁含量增加（+29%），尤其是使骨骼中的锌含量增加（+44%）。TPP使肝脏中的锌和铜含量略有降低。总之，以1 mmol/kg/d的剂量口服给予EDTA、NTA和TPP 35天会引起大鼠组织中某些元素浓度的适度变化，但没有毒性迹象。
