并非所有产生细胞因子的CD8 + T细胞都能抑制猿猴免疫缺陷病毒的复制。
Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication.
作者信息
Chung Chungwon, Lee Wonhee, Loffredo John T, Burwitz Benjamin, Friedrich Thomas C, Giraldo Vela Juan Pablo, Napoe Gnankang, Rakasz Eva G, Wilson Nancy A, Allison David B, Watkins David I
机构信息
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715-1299, USA.
出版信息
J Virol. 2007 Feb;81(3):1517-23. doi: 10.1128/JVI.01780-06. Epub 2006 Nov 29.
Abstract
Current assays of CD8+ T-lymphocyte function measure cytokine production rather than the ability of these lymphocytes to suppress viral replication. Here we show that CD8+ T-cell clones recognizing the same epitope vary enormously in the ability to suppress simian immunodeficiency virus SIVmac239 replication in an in vitro suppression assay. However, all Nef(165-173)IW9- and Vif(66-73)HW8-specific clones from elite controllers effectively suppressed SIV replication. Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2.
摘要
目前对CD8 + T淋巴细胞功能的检测是测定细胞因子的产生，而非这些淋巴细胞抑制病毒复制的能力。在此我们表明，在体外抑制试验中，识别相同表位的CD8 + T细胞克隆在抑制猿猴免疫缺陷病毒SIVmac239复制的能力上差异极大。然而，来自精英控制者的所有Nef(165 - 173)IW9和Vif(66 - 73)HW8特异性克隆均能有效抑制SIV复制。有趣的是，体外抑制效力并不总是与产生γ干扰素、肿瘤坏死因子α或白细胞介素-2的能力相关。
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本文引用的文献
1
Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239.
J Virol. 2006 Jun;80(12):5875-85. doi: 10.1128/JVI.00171-06.
2
The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication.
J Virol. 2006 May;80(10):5074-7. doi: 10.1128/JVI.80.10.5074-5077.2006.
3
Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay.
J Virol. 2005 Dec;79(23):14986-91. doi: 10.1128/JVI.79.23.14986-14991.2005.
4
Clonal breadth of the HIV-1-specific T-cell receptor repertoire in vivo as determined by subtractive analysis.
AIDS. 2005 Jun 10;19(9):887-96. doi: 10.1097/01.aids.0000171402.00372.c2.
5
Cutting Edge: Epitope-dependent effect of Nef-mediated HLA class I down-regulation on ability of HIV-1-specific CTLs to suppress HIV-1 replication.
J Immunol. 2005 Jan 1;174(1):36-40. doi: 10.4049/jimmunol.174.1.36.
6
HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor.
J Exp Med. 2004 Dec 20;200(12):1547-57. doi: 10.1084/jem.20032044. Epub 2004 Dec 13.
7
Identification of seventeen new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognition.
J Immunol. 2004 Oct 15;173(8):5064-76. doi: 10.4049/jimmunol.173.8.5064.
8
HIV and SIV CTL escape: implications for vaccine design.
Nat Rev Immunol. 2004 Aug;4(8):630-40. doi: 10.1038/nri1417.
9
Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load.
J Virol. 2004 Apr;78(7):3233-43. doi: 10.1128/jvi.78.7.3233-3243.2004.
10
Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes.
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