连接到吡咯烷-2-酮环上的β-氨基酸六聚体作为12-螺旋的合成与结构表征。
Synthesis and structural characterisation as 12-helix of the hexamer of a beta-amino acid tethered to a pyrrolidin-2-one ring.
作者信息
Menegazzo Ileana, Fries Alexander, Mammi Stefano, Galeazzi Roberta, Martelli Gianluca, Orena Mario, Rinaldi Samuele
机构信息
Dipartimento di Scienze Chimiche, Università di Padova, ICB-CNR, Via Marzolo 1, I-35131 Padova, Italy.
出版信息
Chem Commun (Camb). 2006 Dec 21(47):4915-7. doi: 10.1039/b612071g. Epub 2006 Oct 10.
DOI:10.1039/b612071g
PMID:17136245
Abstract
Starting from (3S,4R,1'S)-3-amino-2-oxo-1-[1'-(4-methoxyphenylethyl)]pyrrolidine carboxylic acid (2), the first synthesis of a beta-foldamer containing pyrrolidin-2-one rings is described, whose 12-helix conformation is assigned by NMR analysis and confirmed by molecular dynamics (MD) simulations.
摘要
从(3S,4R,1'S)-3-氨基-2-氧代-1-[1'-(4-甲氧基苯乙基)]吡咯烷羧酸(2)开始，描述了含吡咯烷-2-酮环的β-折叠体的首次合成，其12-螺旋构象通过核磁共振分析确定，并经分子动力学(MD)模拟证实。
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