环丁烷β-氨基酸低聚物的 12-螺旋折叠。
12-Helix folding of cyclobutane beta-amino acid oligomers.
机构信息
Clermont Université, Université Blaise Pascal, Laboratoire SEESIB (UMR 6504 - CNRS), 24 avenue des Landais, 63177 Aubière cedex, France.
出版信息
Org Lett. 2010 Aug 20;12(16):3606-9. doi: 10.1021/ol101267u.
PMID:20704401
Abstract
The hexamer and octamer of trans-2-aminocyclobutane carboxylic acid were prepared and their conformational preferences studied experimentally and using molecular modeling. All observations suggest a marked preference for the folding of these oligomers into a well-defined 12-helical conformation, in both solution and the solid state.
摘要
反-2-氨基环丁烷羧酸的六聚体和八聚体被制备出来，并通过实验和分子建模研究了它们的构象偏好。所有的观察结果都表明，这些低聚物在溶液和固态中都非常倾向于折叠成一种明确的 12 螺旋构象。
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