Savel'eva G M, Chekhonin V P, Pavlova T A, Kushch I B, Shalina R I, Rogatkin S O, Morozov S G, Volodin N N
Akush Ginekol (Mosk). 1991 Feb(2):43-6.
The neurospecific protein alpha 1-globulin has been assayed in serum in order to evaluate the blood-brain barrier in newborns with acute intrapartum hypoxia. The study involved 35 term newborns with birth asphyxia of variable severity. The alpha 1-globulin levels correlated with severity of condition at birth, duration of intrauterine exposure to hypoxia and the presence of obstetric complications and clinical severity of cerebral circulatory disorders. A normal early adaptation and effective therapy reduced serum alpha 1-globulin levels 4-8-fold on the 3rd postnatal day and 6-16-fold on the 5th day. Deterioration of neurological symptoms was parallelled by a significant increase in protein levels (to 6400 ng/ml) at day 5. This evidence may confirm the fact that permeability of the blood-brain barrier is impaired by intrapartum hypoxia.
为评估急性分娩期缺氧新生儿的血脑屏障，已对血清中的神经特异性蛋白α1球蛋白进行了检测。该研究纳入了35名足月出生、窒息程度各异的新生儿。α1球蛋白水平与出生时的病情严重程度、宫内缺氧暴露时间、产科并发症的存在以及脑循环障碍的临床严重程度相关。正常的早期适应和有效治疗可使出生后第3天血清α1球蛋白水平降低4至8倍，第5天降低6至16倍。第5天神经症状恶化的同时，蛋白水平显著升高（至6400 ng/ml）。这一证据可能证实了分娩期缺氧会损害血脑屏障通透性这一事实。
