Bradford Timothy J, Tomlins Scott A, Wang Xiaoju, Chinnaiyan Arul M
Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Urol Oncol. 2006 Nov-Dec;24(6):538-51. doi: 10.1016/j.urolonc.2006.07.004.
Although prostate-specific antigen (PSA) has evolved as a very useful tool for detection of prostate cancer, there remains an urgent need for more accurate biomarkers to diagnose prostate cancer and predict cancer-related outcomes. Recent advances in the study of proteomics and high throughput techniques have led to the discovery of many potential biomarkers for prostate cancer. This article briefly reviews the current status of PSA testing and discusses several candidate protein biomarkers for prostate cancer, as well as highlighting some recent proteomic discoveries with the potential to supplement or even replace PSA for the diagnosis and prognosis of prostate cancer.
尽管前列腺特异性抗原（PSA）已发展成为检测前列腺癌的一种非常有用的工具，但仍迫切需要更准确的生物标志物来诊断前列腺癌并预测癌症相关结局。蛋白质组学和高通量技术研究的最新进展已导致发现了许多前列腺癌的潜在生物标志物。本文简要回顾了PSA检测的现状，讨论了几种前列腺癌候选蛋白质生物标志物，并着重介绍了一些最近的蛋白质组学发现，这些发现有可能补充甚至取代PSA用于前列腺癌的诊断和预后评估。
