de Leeuw Reny, Davis C Ervin, Albuquerque Romulo, Carlson Charles R, Andersen Anders H
Orofacial Pain Center, College of Dentistry, University of Kentucky, Lexington, KY 40536-0297, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Dec;102(6):750-7. doi: 10.1016/j.tripleo.2005.12.018. Epub 2006 Jul 14.
The aim of this study was to observe areas of brain activation with painful hot stimulation to the trigeminal nerve.
Nine healthy pain-free women (mean age 26.2 +/- 6.9 yrs) with a natural, regular menstrual cycle participated in the study. Whole-brain functional magnetic resonance imaging (fMRI) data were acquired for each participant on day 2 or 3 after the onset of menses using echo-planar imaging at 1.5T with near-isotropic spatial resolution and a temporal resolution of 4 s.
Whole-brain fMRI with a Peltier thermode inside the head coil yielded a feasible imaging protocol with little disturbance from the thermode. Painful thermal stimulation of the left trigeminal system activated discrete brain regions within the insula, cingulate gyrus, thalamus, inferior parietal lobe/postcentral gyrus, right middle and inferior frontal gyri, cuneus, precuneus, and precentral gyrus.
Painful stimulation of the trigeminal nerve resulted in activation of similar brain areas generally known for pain processing of painful peripheral stimulation.
本研究旨在观察三叉神经受到疼痛性热刺激时的脑激活区域。
9名月经周期自然、规律且无疼痛的健康女性（平均年龄26.2±6.9岁）参与了本研究。在月经开始后的第2天或第3天，使用1.5T的回波平面成像技术，以近各向同性空间分辨率和4秒的时间分辨率，为每位参与者采集全脑功能磁共振成像（fMRI）数据。
在头部线圈内使用珀耳帖热电极进行全脑fMRI，产生了一种可行的成像方案，热电极干扰很小。左侧三叉神经系统的疼痛性热刺激激活了岛叶、扣带回、丘脑、顶下小叶/中央后回、右侧额中回和额下回、楔叶、楔前叶和中央前回内的离散脑区。
三叉神经的疼痛性刺激导致了通常已知用于处理疼痛性外周刺激的类似脑区的激活。
