Bucciarelli Silvia, Cervera Ricard, Espinosa Gerard, Gómez-Puerta José A, Ramos-Casals Manuel, Font Josep
Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, Barcelona, Catalonia, Spain.
Autoimmun Rev. 2006 Dec;6(2):72-5. doi: 10.1016/j.autrev.2006.06.007. Epub 2006 Jul 21.
In order to know the causes of death and the prognostic factors, our group analyzed 250 patients included until February 2005 in the web-site based international registry of patients with catastrophic antiphospholipid syndrome (APS) ("CAPS Registry") (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM). Cerebral involvement, mainly consisting of stroke, followed by cardiac involvement and infections were considered the main causes of death in patients with catastrophic APS. The presence of systemic lupus erythematosus was related with higher mortality. According to the results of this analysis, anticoagulation plus steroids plus plasma exchange should be the first line of therapy in patients with catastrophic APS.
为了解死亡原因及预后因素，我们小组分析了截至2005年2月纳入基于网站的灾难性抗磷脂综合征（APS）患者国际注册数据库（“CAPS注册数据库”）（http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM）的250例患者。脑受累，主要为中风，其次是心脏受累和感染，被认为是灾难性APS患者的主要死亡原因。系统性红斑狼疮的存在与较高死亡率相关。根据该分析结果，抗凝加类固醇加血浆置换应作为灾难性APS患者的一线治疗方案。
