Snyder A Z
Washington University School of Medicine, Department of Neurology and Neurological Surgery, St. Louis, MO 63110.
Electroencephalogr Clin Neurophysiol. 1991 Jul-Aug;80(4):321-5. doi: 10.1016/0168-5597(91)90116-f.
(1) The decision to solve the inverse problem in terms of one or more localized generators implies the assumption of a particular generator model. This assumption permits carrying out inverse dipole estimation. However, it is perilous to justify the procedure on the basis of the result. (2) Goodness of fit is a necessary but not sufficient criterion of model adequacy. A particular quantitative inverse solution has meaning only if it is accompanied by consideration of sensitivity to small changes in all of the free modeling parameters and estimates of perturbing factors including noise and forward calculation uncertainties.
(1) 根据一个或多个局部发生器来解决逆问题的决定意味着采用了特定的发生器模型。这一假设允许进行偶极子逆估计。然而，基于结果来证明该程序的合理性是危险的。(2) 拟合优度是模型充分性的必要但不充分标准。只有在考虑对所有自由建模参数的微小变化的敏感性以及对包括噪声和正向计算不确定性在内的干扰因素进行估计的情况下，特定的定量逆解才有意义。
