孕期螺旋动脉的正常与异常转变。
Normal and abnormal transformation of the spiral arteries during pregnancy.
作者信息
Espinoza Jimmy, Romero Roberto, Mee Kim Yeon, Kusanovic Juan Pedro, Hassan Sonia, Erez Offer, Gotsch Francesca, Than Nandor Gabor, Papp Zoltan, Jai Kim Chong
机构信息
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD 20892, USA.
出版信息
J Perinat Med. 2006;34(6):447-58. doi: 10.1515/JPM.2006.089.
Abstract
This article reviews the anatomy and physiology of the uterine circulation, with emphasis on the remodeling of spiral arteries during normal pregnancy, and the timing and anatomical pathways of trophoblast invasion of the spiral arteries. We review the definitions of the placental bed and basal plate of the placenta, their relevance to the study of the physiologic transformation of the spiral arteries, as well as the methods to obtain and examine placental bed biopsy specimens. We also examine the role of the extravillous trophoblast in normal and abnormal pregnancies, and the criteria used to diagnose failure of physiologic transformation of the spiral arteries. Finally, we comment on the use of uterine artery Doppler velocimetry as a surrogate marker of chronic uteroplacental ischemia.
摘要
本文回顾了子宫循环的解剖学和生理学，重点关注正常妊娠期间螺旋动脉的重塑，以及滋养层细胞侵入螺旋动脉的时间和解剖途径。我们回顾了胎盘床和胎盘基底板的定义、它们与螺旋动脉生理转化研究的相关性，以及获取和检查胎盘床活检标本的方法。我们还研究了绒毛外滋养层细胞在正常和异常妊娠中的作用，以及用于诊断螺旋动脉生理转化失败的标准。最后，我们对使用子宫动脉多普勒测速作为慢性子宫胎盘缺血替代标志物的情况进行了评论。
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Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia.血管内滋养层细胞浸润：对胎儿宫内生长受限和子痫前期发病机制的影响。
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