Kasempimolporn S, Sichanasai B, Saengseesom W, Puempumpanich S, Chatraporn S, Sitprija V
Queen Saovabha Memorial Institute (WHO Collaborating Center for Research on Rabies), Thai Red Cross Society, 1871 Rama IV Road, Bangkok 10330, Thailand.
Prev Vet Med. 2007 Mar 17;78(3-4):325-32. doi: 10.1016/j.prevetmed.2006.11.003. Epub 2006 Dec 4.
To investigate the rabies antigen and antibody prevalences among stray dogs in Bangkok, Thailand, we took both a saliva and serum sample from each of 3314 stray dogs captured once each between December 2003 and June 2004. One 2-year-old female was antigen positive in the latex-agglutination test and confirmed by reverse transcription-polymerase chain reaction. The overall antibody seroprevalence from the enzyme-linked immunosorbent assay that we used was 62% (95% CI: 54, 70%). Antibody seroprevalence was greater for dogs captured within central Bangkok (86% of 1208 dogs captured) than in the dogs captured in the outskirts of the greater metropolitan area (49% of 2106 dogs captured). If our samples of stray dogs are representative, then the seroprevalence achieved from previous vaccination campaigns is too low to protect the dog and human populations.
为调查泰国曼谷流浪狗中狂犬病抗原和抗体的流行情况，我们于2003年12月至2004年6月期间，从3314只流浪狗中各采集一份唾液和血清样本，每只狗仅捕获一次。一只2岁雌性狗在乳胶凝集试验中抗原呈阳性，并经逆转录聚合酶链反应确认。我们使用酶联免疫吸附测定法得出的总体抗体血清阳性率为62%（95%置信区间：54, 70%）。在曼谷市中心捕获的狗（1208只捕获狗中的86%）的抗体血清阳性率高于在大市区郊区捕获的狗（2106只捕获狗中的49%）。如果我们的流浪狗样本具有代表性，那么之前疫苗接种活动所达到的血清阳性率过低，无法保护狗和人类群体。
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