• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鼠伤寒沙门氏菌一个突变体中DNA合成的改变，该突变体使噬菌体P22倾向于溶原状态。

Altered DNA synthesis in a mutant of Salmonella typhimurium that channels bacteriophage P22 toward lysogeny.

作者信息

Steinberg B, Gough M

出版信息

J Virol. 1975 Nov;16(5):1154-60. doi: 10.1128/JVI.16.5.1154-1160.1975.

DOI:10.1128/JVI.16.5.1154-1160.1975
PMID:171446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC355714/
Abstract

Pox-1, a mutant of Salmonella typhimurium, strongly channels P22 toward lysogeny. Viral DNA synthesis in this slow-growing mutant is delayed to a greater extent than viral protein synthesis. The relative enhancement of c2 repressor synthesis results in much higher repressor/DNA synthesis ratios in Pox-1 than in wild-type cells. This probably accounts for the high frequency of lysogenization.

摘要

Pox-1是鼠伤寒沙门氏菌的一种突变体，它强烈地引导P22走向溶原状态。在这个生长缓慢的突变体中，病毒DNA合成比病毒蛋白质合成延迟的程度更大。c2阻遏物合成的相对增强导致Pox-1中阻遏物/DNA合成比率比野生型细胞中的高得多。这可能解释了溶原化的高频率。

相似文献

1
Altered DNA synthesis in a mutant of Salmonella typhimurium that channels bacteriophage P22 toward lysogeny.鼠伤寒沙门氏菌一个突变体中DNA合成的改变，该突变体使噬菌体P22倾向于溶原状态。
J Virol. 1975 Nov;16(5):1154-60. doi: 10.1128/JVI.16.5.1154-1160.1975.
2
Host influence on the activity of genes c1 and c3 in regulating the decision between lysis and lysogency in bacteriophage P22.宿主对噬菌体P22中基因c1和c3活性的影响，该活性参与调控裂解和溶原性之间的抉择。
J Virol. 1975 Nov;16(5):1184-90. doi: 10.1128/JVI.16.5.1184-1190.1975.
3
Mutant of Salmonella typhimurium that channels infecting bacteriophage P22 toward lysogenization.鼠伤寒沙门氏菌的突变体，可引导感染性噬菌体P22走向溶原化。
J Bacteriol. 1974 Aug;119(2):508-13. doi: 10.1128/jb.119.2.508-513.1974.
4
Replication and lysogeny with phage P22 in Salmonella typhimurium.噬菌体P22在鼠伤寒沙门氏菌中的复制与溶原性
Curr Top Microbiol Immunol. 1972;58:135-56. doi: 10.1007/978-3-642-65357-5_4.
5
Bacteriophage-specific DNA-binding proteins in P22-lysogenic and in P22-infected Salmonella typhimurium.P22溶原性及P22感染的鼠伤寒沙门氏菌中的噬菌体特异性DNA结合蛋白。
J Virol. 1976 Oct;20(1):334-8. doi: 10.1128/JVI.20.1.334-338.1976.
6
Regulation of Bacteriophage P22 DNA synthesis and repressor levels in P22cly infections.噬菌体P22cly感染中噬菌体P22 DNA合成及阻遏物水平的调控
J Virol. 1977 Mar;21(3):956-64. doi: 10.1128/JVI.21.3.956-964.1977.
7
Host morphology and phage DNA synthesis following exposure of Salmonella typhimurium (P22 mnt ts 1) to high temperature.鼠伤寒沙门氏菌（P22 mnt ts 1）暴露于高温后宿主形态及噬菌体DNA合成情况
Virology. 1972 Feb;47(2):276-84. doi: 10.1016/0042-6822(72)90263-2.
8
Bacteriophage P22 lysogenises efficiently at high multiplicities of infection because Salmonella typhimurium DNA synthetic capacity is limited.由于鼠伤寒沙门氏菌的DNA合成能力有限，噬菌体P22在高感染复数时能高效地形成溶原菌。
Nature. 1976 Sep 2;263(5572):54-6. doi: 10.1038/263054a0.
9
Delayed lysis in Salmonella phage P22: the continued division of mutant-infected cells actively producing phaage.沙门氏菌噬菌体P22中的延迟裂解：被突变体感染的细胞持续分裂并积极产生噬菌体。
Virology. 1971 Sep;45(3):848-52. doi: 10.1016/0042-6822(71)90212-1.
10
Virulent mutants of phage P22. II. Physiological analysis of P22 virB-3 and its component mutations.噬菌体P22的烈性突变体。II. P22 virB-3及其组成突变的生理学分析。
Virology. 1972 Mar;47(3):644-55. doi: 10.1016/0042-6822(72)90554-5.

引用本文的文献

1
Site c27 in phage P22 and control of the pathway to lysogeny.噬菌体P22中的c27位点与溶原途径的调控
Mol Gen Genet. 1976 Mar 22;144(2):199-204. doi: 10.1007/BF02428109.
2
UV sensitivity of a nonrepressor regulatory protein of bacteriophage P22.噬菌体P22非阻遏调节蛋白的紫外线敏感性
J Virol. 1976 Apr;18(1):65-70. doi: 10.1128/JVI.18.1.65-70.1976.
3
Linkage map of Salmonella typhimurium, edition V.鼠伤寒沙门氏菌连锁图谱，第五版
Microbiol Rev. 1978 Jun;42(2):471-519. doi: 10.1128/mr.42.2.471-519.1978.
4
Effect of mutant host RNA polymerase on the bifunctional activities of P22 gene c1.突变宿主RNA聚合酶对P22基因c1双功能活性的影响
Mol Gen Genet. 1977 Jun 8;153(2):205-10. doi: 10.1007/BF00264737.
5
Regulation of Bacteriophage P22 DNA synthesis and repressor levels in P22cly infections.噬菌体P22cly感染中噬菌体P22 DNA合成及阻遏物水平的调控
J Virol. 1977 Mar;21(3):956-64. doi: 10.1128/JVI.21.3.956-964.1977.
6
Host influence on the activity of genes c1 and c3 in regulating the decision between lysis and lysogency in bacteriophage P22.宿主对噬菌体P22中基因c1和c3活性的影响，该活性参与调控裂解和溶原性之间的抉择。
J Virol. 1975 Nov;16(5):1184-90. doi: 10.1128/JVI.16.5.1184-1190.1975.

本文引用的文献

1
Proline Mutants of Salmonella Typhimurium.鼠伤寒沙门氏菌的脯氨酸突变体
Genetics. 1960 Jun;45(6):755-62. doi: 10.1093/genetics/45.6.755.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
TWO SEQUENTIAL REPRESSIONS OF DNA SYNTHESIS IN THE ESTABLISHMENT OF LYSOGENY BY PHAGE P22 AND ITS MUTANTS.噬菌体P22及其突变体在建立溶原性过程中DNA合成的两次连续抑制
Proc Natl Acad Sci U S A. 1964 Aug;52(2):356-63. doi: 10.1073/pnas.52.2.356.
4
[Defective lysogenic bacteria. II. Physiological types resulting from prophage mutations].[缺陷溶原性细菌。II. 原噬菌体突变产生的生理类型]
Ann Inst Pasteur (Paris). 1957 Dec;93(6):724-53.
5
Mutations in the temperate phage P22 and lysogeny in Salmonella.温和噬菌体P22中的突变与沙门氏菌中的溶原现象
Virology. 1957 Feb;3(1):22-41. doi: 10.1016/0042-6822(57)90021-1.
6
Lysogeny.溶源性
Bacteriol Rev. 1953 Dec;17(4):269-337. doi: 10.1128/br.17.4.269-337.1953.
7
Second locus of bacteriophage P22 necessary for the maintenance of lysogeny.噬菌体P22维持溶原性所必需的第二个位点。
J Virol. 1968 Oct;2(10):992-8. doi: 10.1128/JVI.2.10.992-998.1968.
8
Establishment and maintenance of repression by bacteriophage lambda: the role of the cI, cII, and c3 proteins.噬菌体λ介导的基因沉默的建立与维持：cI、cII和c3蛋白的作用
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2190-4. doi: 10.1073/pnas.68.9.2190.
9
Lysogeny: viral repression and site-specific recombination.溶原性：病毒抑制与位点特异性重组。
Annu Rev Biochem. 1971;40:827-54. doi: 10.1146/annurev.bi.40.070171.004143.
10
Properties of hybrids between Salmonella phage P22 and coliphage lambda.沙门氏菌噬菌体P22与大肠杆菌噬菌体λ之间杂种的特性
Nature. 1974 Oct 18;251(5476):584-9. doi: 10.1038/251584a0.