Zielińska-Jenczylik J, Inglot A D, Inglot O, Popik W
Laboratory of Virology, Polish Academy of Sciences, Wroclaw.
J Interferon Res. 1991 Apr;11(2):87-9.
Transforming growth factor-beta (TGF-beta) at concentration of 10 ng/ml inhibited the development of the interferon-alpha- (IFN-alpha) or IFN-gamma-induced antiviral state in quiescent human embryonic fibroblasts. The action of the cytokines was dose-related; TGF-beta had no direct effect on the replication of either vesicular stomatitis virus (VSV) or encephalomyocarditis virus (EMCV) used as the challenge viruses in the IFN assays. We suggest that despite the fact that TGF-beta acts mainly as a "negative" growth factor, its interactions with IFNs in the antiviral assays resemble known effects of the typical "positive" peptide growth factors.
浓度为10纳克/毫升的转化生长因子-β（TGF-β）抑制静止的人胚胎成纤维细胞中干扰素-α（IFN-α）或干扰素-γ诱导的抗病毒状态的发展。细胞因子的作用呈剂量依赖性；在IFN检测中用作攻击病毒的水疱性口炎病毒（VSV）或脑心肌炎病毒（EMCV）的复制，TGF-β均无直接影响。我们认为，尽管TGF-β主要作为一种“负性”生长因子起作用，但其在抗病毒检测中与IFN的相互作用类似于典型“正性”肽生长因子的已知作用。
