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GermOnline跨物种系统浏览器提供了与有性生殖相关的基因和基因产物的全面信息。

The GermOnline cross-species systems browser provides comprehensive information on genes and gene products relevant for sexual reproduction.

作者信息

Gattiker Alexandre, Niederhauser-Wiederkehr Christa, Moore James, Hermida Leandro, Primig Michael

机构信息

Biozentrum & Swiss Institute of Bioinformatics, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland.

出版信息

Nucleic Acids Res. 2007 Jan;35(Database issue):D457-62. doi: 10.1093/nar/gkl957. Epub 2006 Dec 1.

Abstract

We report a novel release of the GermOnline knowledgebase covering genes relevant for the cell cycle, gametogenesis and fertility. GermOnline was extended into a cross-species systems browser including information on DNA sequence annotation, gene expression and the function of gene products. The database covers eight model organisms and Homo sapiens, for which complete genome annotation data are available. The database is now built around a sophisticated genome browser (Ensembl), our own microarray information management and annotation system (MIMAS) used to extensively describe experimental data obtained with high-density oligonucleotide microarrays (GeneChips) and a comprehensive system for online editing of database entries (MediaWiki). The RNA data include results from classical microarrays as well as tiling arrays that yield information on RNA expression levels, transcript start sites and lengths as well as exon composition. Members of the research community are solicited to help GermOnline curators keep database entries on genes and gene products complete and accurate. The database is accessible at http://www.germonline.org/.

摘要

我们报告了GermOnline知识库的一次新发布,其涵盖了与细胞周期、配子发生和生育力相关的基因。GermOnline已扩展为一个跨物种系统浏览器,包含DNA序列注释、基因表达及基因产物功能等信息。该数据库涵盖了八种模式生物和智人,可获取其完整的基因组注释数据。目前,该数据库围绕一个复杂的基因组浏览器(Ensembl)、我们自己用于广泛描述通过高密度寡核苷酸微阵列(基因芯片)获得的实验数据的微阵列信息管理与注释系统(MIMAS)以及一个用于在线编辑数据库条目的综合系统(MediaWiki)构建。RNA数据包括经典微阵列以及平铺阵列的结果,这些结果可提供RNA表达水平、转录起始位点和长度以及外显子组成等信息。我们邀请研究界成员协助GermOnline的管理人员,以确保关于基因和基因产物的数据库条目完整且准确。该数据库可通过http://www.germonline.org/访问。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4744/1781232/4e42853c6bd7/gkl957f1.jpg

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