Uduman S A, Gershon A A, Brunell P A
JAMA. 1975 Dec 8;234(10):1049-51.
Zoster developed in 55 patients, and 15, generalized disease occurred. Twelve of 14 patients with dissemination had prompt appearance of both complement-fixing (CF) antibody and fluorescent antibody against varicella-zoster (VS) membrane antigen (FAMA). The geometric mean titers of VZ antibody from the first to the fifth and the sixth through the tenth days following onset of zoster were similar in patients with localized and generalized involvement. Two patients with disseminated zoster had undetectable CF antibody, but VZ FAMA was demonstrable. Because the clinical course of zoster appears to be unrelated to the serologic response to VZ virus, it is unlikely that administration of antibody with zoster would be benefit in this disease.
55例患者发生了带状疱疹，其中15例出现了播散性疾病。14例播散性患者中有12例在出现水痘-带状疱疹（VS）膜抗原补体结合（CF）抗体和荧光抗体（FAMA）后迅速出现症状。带状疱疹发病后第1至5天和第6至10天，局限性和播散性受累患者的VZ抗体几何平均滴度相似。2例播散性带状疱疹患者检测不到CF抗体，但可检测到VZ FAMA。由于带状疱疹的临床病程似乎与对VZ病毒的血清学反应无关，因此在这种疾病中给予抗体不太可能有益。
