Gershon A A, Steinberg S P
Am J Med Sci. 1981 Jul-Aug;282(1):12-7. doi: 10.1097/00000441-198107000-00002.
Antibody titers to varicella-zoster (VZ) virus in persons aged 1-85 years were measured. Through age 50, the percent of seropostitive individuals continued to rise. There was no fall in geometric mean titer with aging, and there may have been an increase in VZ antibody titer in older persons. Thus, a fall in VZ antibody with increasing age does not seem likely to account for the increased incidence of zoster in the elderly. Similarly, immunocompromised patients who are more likely to develop zoster than normals did not have lower VZ antibody titers than normal persons. Finally, immunocompromised persons with disseminated zoster had antibody titers that were somewhat higher that those of immunocompromised persons with localized zoster. It appears that humoral immunity has little or no influence on either the development or the course of herpes zoster.
对1至85岁人群的水痘 - 带状疱疹（VZ）病毒抗体滴度进行了测量。到50岁时，血清反应阳性个体的百分比持续上升。几何平均滴度并未随年龄增长而下降，老年人的VZ抗体滴度可能还有所上升。因此，VZ抗体随年龄增长而下降似乎不太可能是老年人带状疱疹发病率增加的原因。同样，与正常人相比更容易发生带状疱疹的免疫功能低下患者，其VZ抗体滴度并不低于正常人。最后，患有播散性带状疱疹的免疫功能低下者的抗体滴度，略高于患有局限性带状疱疹的免疫功能低下者。看来体液免疫对带状疱疹的发生或病程几乎没有影响。
