Coop Graham, Przeworski Molly
Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.
Nat Rev Genet. 2007 Jan;8(1):23-34. doi: 10.1038/nrg1947. Epub 2006 Dec 5.
Recombination has essential functions in mammalian meiosis, which impose several constraints on the recombination process. However, recent studies have shown that, in spite of these roles, recombination rates vary tremendously among humans, and show marked differences between humans and closely related species. These findings provide important insights into the determinants of recombination rates and raise new questions about the selective pressures that affect recombination over different genomic scales, with implications for human genetics and evolutionary biology.
重组在哺乳动物减数分裂中具有重要功能，这对重组过程施加了若干限制。然而，最近的研究表明，尽管有这些作用，但重组率在人类中差异极大，并且在人类与亲缘关系密切的物种之间存在显著差异。这些发现为重组率的决定因素提供了重要见解，并引发了关于在不同基因组尺度上影响重组的选择压力的新问题，对人类遗传学和进化生物学具有重要意义。
