Dolbakyan E E, Merzhanova G Kh
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Neurosci Behav Physiol. 2007 Sep;37(7):679-88. doi: 10.1007/s11055-007-0068-6.
An operant food-related conditioned reflex was developed in six cats by the "active choice" protocol: short-latency pedal presses were followed by presentation of low-quality reinforcement (bread-meat mix), while long-latency pedal presses were followed by presentation of high-quality reinforcement (meat). Animals differed in terms of their food-procuring strategies, displaying "self-control," "ambivalence," or "impulsivity." Multineuron activity was recorded from the frontal cortex and hippocampus (field CA3). Cross-correlation analysis of interneuronal interactions within (local networks) and between (distributed networks) study structures showed that the numbers of interneuronal interactions in both local and distributed networks were maximal in animals with "self-control." On the background of systemic administration of the muscarinic cholinoreceptor blockers scopolamine and trihexyphenidyl, the numbers of interneuronal interactions decreased, while "common source" influences increased. This correlated with impairment of the reproduction of the selected strategy, primarily affecting the animals' self-controlled behavior. These results show that the "self-control" strategy is determined by the organization of local and distributed networks in the frontal cortex and hippocampus.
通过“主动选择”方案在六只猫身上建立了一种与食物相关的操作性条件反射：短潜伏期踏板按压后呈现低质量强化物（面包 - 肉混合物），而长潜伏期踏板按压后呈现高质量强化物（肉）。动物在获取食物的策略方面存在差异，表现出“自我控制”“矛盾心理”或“冲动性”。从额叶皮质和海马体（CA3区）记录多神经元活动。对研究结构内部（局部网络）和之间（分布式网络）的神经元间相互作用进行互相关分析表明，在具有“自我控制”的动物中，局部和分布式网络中的神经元间相互作用数量最多。在全身给予毒蕈碱型胆碱能受体阻滞剂东莨菪碱和苯海索的背景下，神经元间相互作用数量减少，而“共同来源”影响增加。这与所选策略再现的受损相关，主要影响动物的自我控制行为。这些结果表明，“自我控制”策略由额叶皮质和海马体中局部和分布式网络的组织所决定。
