Dubrovina N I, Tomilenko R A, Obut T A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Sep-Oct;56(5):684-90.
It was shown that injections of NMDA receptor antagonist dizocilpine and neurosteroid dehydroepiandrosterone sulfate (DHEAS) and sequential injections of these substances had different effects on learning and extinction of passive avoidance in aggressive and submissive mice. In aggressive mice, dizocilpine impaired and DHEAS did not change learning and retention. However, being injected after dizocilpine, DHEAS blocked the defect of memory trace retrieval induced by dizocilpine. In submissive mice, dizocilpine impaired learning and prolonged extinction of the learned habit. Injection of DHEAS prolonged the extinction in a similar way. Under conditions of sequential injections, DHEAS did not change the suppressive effect of dizocilpine on learning and was not effective in prolongation of extinction.
结果表明，注射NMDA受体拮抗剂地佐环平、神经甾体硫酸脱氢表雄酮（DHEAS）以及顺序注射这些物质，对攻击性和顺从性小鼠被动回避学习和消退的影响不同。在攻击性小鼠中，地佐环平损害学习和记忆保持，而DHEAS对其没有影响。然而，在注射地佐环平后再注射DHEAS，可阻断地佐环平诱导的记忆痕迹提取缺陷。在顺从性小鼠中，地佐环平损害学习并延长习得习惯的消退时间。注射DHEAS也以类似方式延长消退时间。在顺序注射的情况下，DHEAS不改变地佐环平对学习的抑制作用，且在延长消退时间方面无效。
