Tomilenko R A, Dubrovina N I
Ross Fiziol Zh Im I M Sechenova. 2006 Mar;92(3):342-50.
Influence of agonist (D-cycloserine) and antagonist (dizocilpine) N-methyl-D-aspartate receptors on learning and extinction of passive avoidance response in medium-, high-, and low-anxious mice was studied. In medium-anxious mice, D-cycloserine (30 mg/kg) although not changing learning accelerated development of extinction, whereas dizocilpine (0.15 mg/kg), while impairing passive avoidance learning, detained the extinction. In high-anxious mice with good retrieval of memory trace and absence of extinction, D-cycloserine was ineffective, whereas dizocilpine reduced learning and promoted retention of memory trace retrieval at the generated level on extinction. In low-anxious mice, D-cycloserine impaired learning and accelerated extinction, whereas dizocilpine completely blocked learning and retention of passive avoidance response.
研究了激动剂（D - 环丝氨酸）和拮抗剂（地卓西平）N - 甲基 - D - 天冬氨酸受体对中、高、低焦虑小鼠被动回避反应学习和消退的影响。在中度焦虑小鼠中，D - 环丝氨酸（30毫克/千克）虽然不改变学习，但加速了消退的发展，而地卓西平（0.15毫克/千克）在损害被动回避学习的同时，延缓了消退。在具有良好记忆痕迹恢复且无消退的高焦虑小鼠中，D - 环丝氨酸无效，而地卓西平降低了学习并促进了在消退时产生水平上记忆痕迹恢复的保留。在低焦虑小鼠中，D - 环丝氨酸损害学习并加速消退，而地卓西平完全阻断了被动回避反应的学习和保留。
