Peers S H, Flower R J
Pharmacology Group, University of Bath, Claverton Down, U.K.
Eur J Pharmacol. 1991 Apr 10;196(1):37-41. doi: 10.1016/0014-2999(91)90406-g.
Systemic pretreatment of rabbits with dexamethasone results in a time-dependent inhibition of oedema responses caused by intradermal injection of both 'direct-acting' and 'neutrophil-dependent' stimuli. Local injection of actinomycin D, an inhibitor of RNA synthesis, inhibits this effect. Our studies suggest that a major action of dexamethasone in this model may be a local inhibition of increased permeability of the vascular endothelium.
用地塞米松对兔子进行全身预处理，会导致皮内注射“直接作用”和“中性粒细胞依赖性”刺激所引起的水肿反应出现时间依赖性抑制。局部注射RNA合成抑制剂放线菌素D可抑制这种效应。我们的研究表明，在该模型中，地塞米松的主要作用可能是局部抑制血管内皮通透性增加。
