Brain S D, Williams T J
Br J Pharmacol. 1985 Dec;86(4):855-60. doi: 10.1111/j.1476-5381.1985.tb11107.x.
The potent vasodilator calcitonin gene-related peptide (CGRP, human synthetic), when mixed with histamine and injected intradermally in the rabbit, induced a marked potentiation of local oedema. CGRP also potentiated oedema induced by other mediators of increased microvascular permeability in the rabbit; bradykinin, platelet-activating factor (Paf), C5a des Arg, N-formylmethionyl-leucyl-phenylalanine (FMLP) and leukotriene B4 (LTB4). Substance P alone, or mixtures of substance P and CGRP, failed to induce oedema in rabbit skin. In rat skin, however, substance P induced oedema and this was potentiated by CGRP. CGRP had a protracted potentiating action following intradermal injection in the rabbit. The time for half loss of activity for CGRP was 40.1 +/- 7.5 min compared to 18 +/- 1 min for prostaglandin E2 (PGE2). No loss of potentiating activity was detected after incubation of CGRP in rabbit plasma or blood for 60 min. We postulate that endogenous CGRP, if released locally from nerve endings, could have a marked enhancing effect on oedema induced by other mediators in an inflammatory reaction.
强效血管舒张剂降钙素基因相关肽（CGRP，人工合成的人源型）与组胺混合后皮内注射到兔子体内时，会显著增强局部水肿。CGRP还能增强兔子体内其他微血管通透性增加介质所诱导的水肿，这些介质包括缓激肽、血小板活化因子（PAF）、C5a去精氨酸产物、N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）和白三烯B4（LTB4）。单独的P物质，或P物质与CGRP的混合物，均不能在兔皮中诱导水肿。然而，在大鼠皮肤中，P物质可诱导水肿，且CGRP能增强这种水肿。在兔子皮内注射后，CGRP具有持久的增强作用。CGRP活性丧失一半的时间为40.1±7.5分钟，而前列腺素E2（PGE2）为18±1分钟。将CGRP在兔血浆或血液中孵育60分钟后，未检测到增强活性的丧失。我们推测，如果内源性CGRP从神经末梢局部释放，可能会对炎症反应中其他介质诱导的水肿产生显著的增强作用。
