Mailund Thomas, Schierup Mikkel H, Pedersen Christian N S, Madsen Jesper N, Hein Jotun, Schauser Leif
Bioinformatics Research Center, University of Aarhus Høegh-Guldbergs Gade 10, DK-8000 Arhus C, Denmark.
Bioinformatics. 2006 Sep 15;22(18):2317-8. doi: 10.1093/bioinformatics/btl153. Epub 2006 Apr 21.
GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and microsatellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis-Hastings sampling in the state space of genealogies. Input format, search strategy and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable.
The source code for GeneRecon, written in C++ and Scheme, is available under the GNU General Public License (GPL) at http://www.birc.au.dk/~mailund/GeneRecon
GeneRecon是一种使用合并模型进行精细尺度关联映射的工具。GeneRecon将来自分阶段或未分阶段的单核苷酸多态性（SNP）和微卫星基因型的病例对照数据作为输入。通过在系谱的状态空间中进行Metropolis-Hastings采样来获得疾病位点位置的后验分布。输入格式、搜索策略和采样统计信息可以通过GeneRecon中嵌入的Guile Scheme编程语言进行配置，这使得GeneRecon具有高度的可配置性。
用C++和Scheme编写的GeneRecon的源代码可在GNU通用公共许可证（GPL）下从http://www.birc.au.dk/~mailund/GeneRecon获得。
