Frydenberg M, Foo T M, Jones A S, Grace J, Hensley W J, Rogers J, Pearson B S, Raghavan D
Urological Cancer Research Unit, Royal Prince Alfred Hospital, Sydney, Australia.
J Urol. 1991 Sep;146(3):872-6. doi: 10.1016/s0022-5347(17)37951-x.
Androgens are essential for the development and maintenance of the prostate. However, prostatic growth may be mediated by epidermal growth factor (EGF) and the expression of the EGF receptor (EGFR) may be influenced by the androgenic milieu. We have characterized the expression of cytosolic androgen receptor (ARc), nuclear salt extractable androgen receptor (ARn) and EGFR in 89 consecutive cases of benign prostatic hyperplasia, 84 of which were treated by transurethral prostatic resections. Image analysis morphometry was performed on the histological sections to determine the epithelial content of the gland. Our results indicate that there is a vast heterogeneity of receptor expression in benign prostatic hyperplasia. Expression of ARc ranged from zero to 1312 fmol/gm. tissue (mean +/- SD 265 +/- 290), ARn ranged from zero to 531 fmol/gm. tissue (mean +/- SD 145 +/- 98) and EGFR ranged from zero to 316 fmol/gm. tissue (mean +/- SD 121 +/- 76). A statistically significant association was found between expression of ARn and EGFR, and these were both significantly correlated with the epithelial content of the gland.
雄激素对于前列腺的发育和维持至关重要。然而，前列腺生长可能由表皮生长因子（EGF）介导，并且表皮生长因子受体（EGFR）的表达可能受雄激素环境的影响。我们对89例连续的良性前列腺增生病例中的胞质雄激素受体（ARc）、核盐可提取雄激素受体（ARn）和EGFR的表达进行了表征，其中84例接受了经尿道前列腺切除术。对组织学切片进行图像分析形态测量以确定腺体的上皮含量。我们的结果表明，良性前列腺增生中受体表达存在巨大异质性。ARc的表达范围为0至1312 fmol/g组织（平均±标准差265±290），ARn的表达范围为0至531 fmol/g组织（平均±标准差145±98），EGFR的表达范围为0至316 fmol/g组织（平均±标准差121±76）。发现ARn和EGFR的表达之间存在统计学上的显著关联，并且它们均与腺体的上皮含量显著相关。
