一种从常绿黄杨中提取生物碱布克嗪-C的简短而高效的方法。

Short and efficient approach towards buxozine-C, an alkaloid from Buxus sempervirens.

作者信息

Liu Hai-Feng, Ji Min, Cai Jin

机构信息

Institute of Pharmaceutical Engineering, Department of Chemistry and Chemical Engineering, Southeast University, Nanjing, P.R. China.

出版信息

Arch Pharm (Weinheim). 2006 Dec;339(12):675-6. doi: 10.1002/ardp.200600063.

DOI:10.1002/ardp.200600063

PMID:17149794

Abstract

Buxus alkaloids display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards one of the alkaloids, buxozine-C. The first synthesis has been achieved with 91% yield starting from cyclovirobuxine-D by forming a tetrahydro-oxazine ring with formaldehyde at room temperature.

摘要

黄杨生物碱具有广泛有趣的药理活性。在此，我们展示了一种合成其中一种生物碱——环维黄杨星C的简短且高效的方法。首次合成是从环维黄杨星D出发，在室温下与甲醛形成四氢恶嗪环，产率达91%。