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本文引用的文献
1
Elucidation of enzyme mechanisms using fluorinated substrate analogues.
Bioorg Chem. 2004 Oct;32(5):393-437. doi: 10.1016/j.bioorg.2004.06.012.
2
Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor.
J Med Chem. 2003 Dec 4;46(25):5292-3. doi: 10.1021/jm034162s.
3
Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens.
J Biol Chem. 1959 Apr;234(4):932-6.
4
The gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase of beef brain.
J Biol Chem. 1958 Nov;233(5):1135-9.
5
Metabolism of fluorine-containing drugs.
Annu Rev Pharmacol Toxicol. 2001;41:443-70. doi: 10.1146/annurev.pharmtox.41.1.443.
6
A new class of conformationally rigid analogues of 4-amino-5-halopentanoic acids, potent inactivators of gamma-aminobutyric acid aminotransferase.
J Med Chem. 2000 Feb 24;43(4):706-20. doi: 10.1021/jm9904755.
7
Inactivation of the reconstituted oxoglutarate carrier from bovine heart mitochondria by pyridoxal 5'-phosphate.
J Bioenerg Biomembr. 1999 Dec;31(6):535-41. doi: 10.1023/a:1026414826457.
8
The multiple active enzyme species of gamma-aminobutyric acid aminotransferase are not isozymes.
Arch Biochem Biophys. 2000 Feb 15;374(2):248-54. doi: 10.1006/abbi.1999.1623.
9
Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase.
J Med Chem. 1999 Nov 4;42(22):4725-8. doi: 10.1021/jm990271o.
10
Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine.
Synapse. 1999 Oct;34(1):11-9. doi: 10.1002/(SICI)1098-2396(199910)34:1<11::AID-SYN2>3.0.CO;2-5.
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