Camero Michele, Bellacicco Anna Lucia, Tarsitano Elvira, Decaro Nicola, Martella Vito, Tempesta Maria, Buonavoglia Canio
Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, Strada P.le per Casamassima km 3, 70010 Valenzano, Italy.
Vaccine. 2007 Feb 19;25(9):1658-61. doi: 10.1016/j.vaccine.2006.11.002. Epub 2006 Nov 13.
To evaluate the efficacy of mucosal vaccination with a beta-propiolactone inactivated caprine herpesvirus-1 (CpHV-1) vaccine, goats received vaginal administrations of two 7-day cycles at 2 weeks intervals. Seven days after the end of the second cycle, goats were challenged intravaginally with 4 ml of virulent BA.1 strain of CpHV-1. Vaccinated goats shed challenge virus for 8 days but, in comparison with control unvaccinated-challenged goats, were significantly protected from the classical clinical signs of genital lesions. Even without adjuvants, prolonged mucosal vaccination induced production of secretory IgA and provided significant clinical protection.
为评估用β-丙内酯灭活的山羊疱疹病毒1型（CpHV-1）疫苗进行黏膜疫苗接种的效果，山羊每隔2周接受两个7天周期的阴道给药。在第二个周期结束后7天，给山羊阴道内接种4毫升CpHV-1的强毒株BA.1。接种疫苗的山羊排出攻击病毒达8天，但与未接种疫苗而接受攻击的对照山羊相比，它们受到显著保护，未出现典型的生殖器损伤临床症状。即使没有佐剂，延长的黏膜疫苗接种也诱导了分泌型IgA的产生，并提供了显著的临床保护。
