Oyama H, Okamura K, Watanabe M, Nakamura S, Yamamoto M
Department of Neurosurgery, Toyohashi Municipal Hospital, Aichi, Japan.
Neurol Med Chir (Tokyo). 1991 Mar;31(3):146-51. doi: 10.2176/nmc.31.146.
The authors report malignant glioma occurring in two sibling cases. The elder brother presented with right hemiparesis and hemihypesthesia at 14-year-old. Computed tomographic (CT) scanning demonstrated a low-density area in the left frontoparietal lobe. The tumor was partially removed. Histologic diagnosis was glioblastoma multiforme. Radiation therapy was given postoperatively, but he died due to tumor recurrence 15 months after onset. The younger sister was admitted comatose due to intratumoral bleeding at 19-year-old. CT scans showed a high-density area in the right temporal lobe. The tumor was excised subtotally. Histological diagnosis was malignant astrocytoma (grade III). Radiation therapy, chemotherapy (ACNU), and immunotherapy (interferon) were given postoperatively, but she died due to recurrence 34 months after onset.
作者报告了两例同胞患恶性胶质瘤的病例。哥哥14岁时出现右侧偏瘫和偏身感觉减退。计算机断层扫描（CT）显示左侧额顶叶有一个低密度区。肿瘤被部分切除。组织学诊断为多形性胶质母细胞瘤。术后进行了放射治疗，但他在发病15个月后因肿瘤复发死亡。妹妹19岁时因肿瘤内出血昏迷入院。CT扫描显示右侧颞叶有一个高密度区。肿瘤被次全切除。组织学诊断为恶性星形细胞瘤（III级）。术后给予了放射治疗、化疗（阿糖胞苷）和免疫治疗（干扰素），但她在发病34个月后因复发死亡。
