Urata Hidehito, Fujimori Mami, Aono Chie, Hrada Emi, Matsumoto Tomoko, Yamakawa Tomomi, Akagi Masao
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Nucleic Acids Symp Ser (Oxf). 2005(49):115-6. doi: 10.1093/nass/49.1.115.
We have reported that the oligomerization of racemic mononucleotides catalyzed by montmorillonite clay proceeds efficiently and gives up to 8-mer. Here, we attempted to identify the dimer products to show the characteristics of the racemic reaction. The results suggested that homochiral pApAs are formed in somewhat higher yield than heterochiral pApAs. Therefore, the oligomerization of racemic mononucleotides catalyzed by montmorillonite shows the homochiral selectivity.
我们曾报道，蒙脱石催化的外消旋单核苷酸低聚反应高效进行，可生成高达8聚体。在此，我们试图鉴定二聚体产物以展现外消旋反应的特征。结果表明，同手性的pApA形成的产率略高于异手性的pApA。因此，蒙脱石催化的外消旋单核苷酸低聚反应表现出同手性选择性。
