Urata Hidehito, Fujimori Mami, Aono Chie, Yamakawa Tomomi, Harada Emi, Akagi Masao
Osaka University of Pharmaceutical Sciences, Osaka, Japan.
Nucleosides Nucleotides Nucleic Acids. 2008 Apr;27(4):421-30. doi: 10.1080/15257770801954955.
Clay is a possible candidate for an effective catalyst in prebiotic chemical evolution of biomolecules. Montmorillonite was reported to effectively catalyze oligomerization of racemic adenosine 5'-phosphorimidazolide (DL-ImpA). In the oligomerization reaction, considerable amounts of cyclic dimers as well as linear dimers were produced in the oligomerization reactions. To assess the regio- and diastereo-selectivities of the oligomerization reaction, the dimer products including cyclic dimers were completely identified by means of enzymatic degradation reactions of the products.
黏土是生物分子益生元化学进化中有效催化剂的一个可能候选物。据报道，蒙脱石能有效催化外消旋腺苷5'-磷酰咪唑（DL-ImpA）的低聚反应。在低聚反应中，低聚反应产生了大量的环状二聚体以及线性二聚体。为了评估低聚反应的区域选择性和非对映选择性，通过产物的酶促降解反应完全鉴定了包括环状二聚体在内的二聚体产物。
