Hashimoto C
Department of Internal Medicine, Fukushima Medical College.
Tohoku J Exp Med. 1990 Dec;162(4):323-35. doi: 10.1620/tjem.162.323.
Peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE) proliferated spontaneously and secreted an elevated level of IgG compared with that of normal controls. However, the levels of interleukin-6 (IL-6) produced by PBMC from patients with SLE with or without pokeweed mitogen (PWM) stimulation showed no significant difference from those of normal controls. The levels of IL-6 secreted spontaneously from PBMC of SLE patients correlated inversely with the percent and the absolute number of CD19 positive cells in PBMC, but not with the levels of IgG and IgM secreted spontaneously from PBMC. There was no significant difference in the levels of IgG produced by PBMC stimulated with IL-6 and also in the levels of IL-6 synthetized by T and B cells between SLE patients and normal controls. These data suggest that IL-6 may not play an important role in the hypergammaglobulinemia in SLE.
与正常对照组相比，系统性红斑狼疮（SLE）患者的外周血单个核细胞（PBMC）自发增殖并分泌高水平的IgG。然而，无论有无商陆有丝分裂原（PWM）刺激，SLE患者的PBMC产生的白细胞介素-6（IL-6）水平与正常对照组相比均无显著差异。SLE患者PBMC自发分泌的IL-6水平与PBMC中CD19阳性细胞的百分比和绝对数量呈负相关，但与PBMC自发分泌的IgG和IgM水平无关。SLE患者和正常对照组之间，IL-6刺激PBMC产生的IgG水平以及T和B细胞合成的IL-6水平均无显著差异。这些数据表明，IL-6可能在SLE的高丙种球蛋白血症中不起重要作用。
