Kogure A, Ohshima Y, Watanabe N, Ohba T, Miyata M, Ohara M, Nishimaki T, Kasukawa R
Department of Internal Medicine II, Fukushima Medical College, Japan.
Clin Rheumatol. 1995 Mar;14(2):199-203. doi: 10.1007/BF02214944.
The case of a 40-year-old woman with Werner's syndrome associated with systemic lupus erythematosus (SLE) is reported. The patient exhibited short stature, slender extremities, thinned hair, high-pitched voice, cataracts, ulceration of the fingers, and mental retardation. Malar erythema, photosensitivity, and proteinuria had been noted since age 34. The serum contained high titers of antibodies to dsDNA, Sm, nRNP, and SS-A/Ro. The simultaneous presence of Werner's syndrome and SLE could be a coincidental occurrence of the two diseases, although it might be due to an abnormality in replication or degeneration of DNA leading to the development of both diseases.
报告了一例40岁患有韦纳综合征并伴有系统性红斑狼疮（SLE）的女性病例。该患者表现为身材矮小、四肢细长、头发稀疏、声音高亢、白内障、手指溃疡和智力发育迟缓。自34岁起就已发现有颧部红斑、光敏性和蛋白尿。血清中含有高滴度的抗双链DNA、Sm、核核糖核蛋白（nRNP）和SS - A/Ro抗体。韦纳综合征和SLE同时出现可能是这两种疾病的偶然并发，尽管这可能是由于DNA复制或变性异常导致两种疾病的发生。
