Takenaka Yusuke
The Japanese Society for History of Pharmacy.
Yakushigaku Zasshi. 2006;41(1):18-26.
"Curare and Claude BERNARD" is a well known set of physiology in several western scientific and medical communities. In using arrow poison curare as a tool of physiological anatomical approach, Bernard founded the experimental physiology of the nervous system. His famous experiments of using curare on frogs led to the observation of curare block in the myoneural junction of skeletal muscle. Bernard's achievements in curare research are recorded in full detail in his principal book of lectures, "Leçons sur les effets des substances toxiques et medicamenteuses (1857)". Nevertheless, Japanese physiological communities, attaching too much importance to German physiology between the end of the 19th century and the beginning of the 20th century, have mostly neglected the important work on curare done by Bernard, and the after-effect of this neglect is on-going in Japan. The aim of this article is to try to enlighten the communities with a small part of his lectures (i.e., arrow poison curare) described in "Leçons (1857)", which never reached us.
“箭毒与克洛德·贝尔纳”在西方多个科学和医学界是一套广为人知的生理学内容。贝尔纳将箭毒这种箭毒作为生理解剖学方法的工具，创立了神经系统实验生理学。他在青蛙身上使用箭毒的著名实验，导致了在骨骼肌肌神经接头处观察到箭毒阻滞现象。贝尔纳在箭毒研究方面的成就，在他的主要讲稿《关于有毒和药用物质的作用》（1857年）中有详细记载。然而，在19世纪末至20世纪初，日本生理学领域过于重视德国生理学，大多忽视了贝尔纳在箭毒方面所做的重要工作，这种忽视的后果在日本一直持续。本文旨在通过他的讲稿《关于有毒和药用物质的作用》（1857年）中未流传到我们这里的一小部分内容（即箭毒）来启发相关领域。
