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应激性衰老加速反应试验应激（反复冷应激）大鼠中枢神经系统中血清素及其代谢物水平的变化。

Changes in CNS levels of serotonin and its metabolite in SART-stressed (repeatedly cold-stressed) rats.

作者信息

Hata T, Itoh E, Kawabata A

机构信息

Department of Pharmacology, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.

出版信息

Jpn J Pharmacol. 1991 May;56(1):101-4. doi: 10.1254/jjp.56.101.

DOI:10.1254/jjp.56.101
PMID:1715412
Abstract

Central nervous system levels of serotonin (5-HT) and 5-hydroxy-indoleacetic acid (5-HIAA) in SART (specific alternation of rhythm in temperature)-stressed (repeatedly cold-stressed) rats were examined by HPLC-ECD. In SART-stressed rats, the levels of both 5-HT and 5-HIAA decreased in many brain areas. In the spinal cord, only the 5-HT level decreased. Therefore, the ratio of 5-HIAA to 5-HT increased only in the spinal cord. These results suggest that SART-stressed rats have some form of abnormality in the synthetic system of 5-HT.

摘要

通过高效液相色谱 - 电化学检测法（HPLC - ECD）检测了在特定温度节律交替应激（反复冷应激）的大鼠中，血清素（5 - HT）和5 - 羟吲哚乙酸（5 - HIAA）在中枢神经系统中的水平。在特定温度节律交替应激的大鼠中，5 - HT和5 - HIAA在许多脑区的水平均下降。在脊髓中，仅5 - HT水平下降。因此，5 - HIAA与5 - HT的比值仅在脊髓中升高。这些结果表明，特定温度节律交替应激的大鼠在5 - HT合成系统中存在某种形式的异常。

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