Souza S M C, Aquino L C M, Milach A C, Bandeira M A M, Nobre M E P, Viana G S B
Department of Biophysiology, Faculty of Medicine of Juazeiro do Norte, Av. Tenente Raimundo Rocha, s/n, Juazeiro do Norte, CE 63040-000, Brazil.
Phytother Res. 2007 Mar;21(3):220-5. doi: 10.1002/ptr.2011.
Myracrodruon urundeuva Allemão is a plant utilized in Northeast Brazil as an antiinflammatory, wound healing and in gynecological illnesses. The objectives of the present study were to evaluate the antiinflammatory and antiulcer properties of the tannin-enriched fraction (TEF) isolated from the stem bark of M. urundeuva, in the formalin test, in mice, and in carrageenan-induced paw edema and gastric ulcer models, in rats. The results showed that TEF dose-dependently inhibited both phases of the formalin test. However, the effect was predominant in the 2nd phase of the response where inhibitions of 47%, 76% and 85% were observed, with doses of 5, 10 and 50 mg/kg, i.p. In the carrageenan-induced paw edema, significant inhibitions were observed at 3 h (44%) and 4 h (28%), with a dose of 10 mg/kg, i.p. TEF also significantly decreased by 37%, 43% and 57% gastric ulceration induced by indomethacin, at doses of 10, 20 and 50 mg/kg p.o. In the ethanol-induced gastric ulcer model, TEF was less effective, and significant inhibitions (42% to 46%) were observed only with doses of 100 and 200 mg/kg, p.o., respectively. In conclusion, it was shown that TEF presents antiinflammatory and antiulcer effects, partly due to its antioxidant action, known to be present in polyphenols, including tannins.
巴西胡桃木是一种生长在巴西东北部的植物，被用作抗炎、促进伤口愈合以及治疗妇科疾病。本研究的目的是评估从巴西胡桃木茎皮中分离出的富含单宁的组分（TEF）在小鼠福尔马林试验、大鼠角叉菜胶诱导的爪肿胀和胃溃疡模型中的抗炎和抗溃疡特性。结果表明，TEF对福尔马林试验的两个阶段均有剂量依赖性抑制作用。然而，该作用在反应的第二阶段更为显著，腹腔注射5、10和50 mg/kg剂量的TEF时，抑制率分别为47%、76%和85%。在角叉菜胶诱导的爪肿胀模型中，腹腔注射10 mg/kg剂量的TEF在3小时（44%）和4小时（28%）时产生显著抑制作用。TEF还能显著降低吲哚美辛诱导的胃溃疡，口服10、20和50 mg/kg剂量时，溃疡抑制率分别为37%、43%和57%。在乙醇诱导的胃溃疡模型中，TEF的效果较差，仅在口服100和200 mg/kg剂量时分别产生显著抑制作用（42%至46%）。总之，研究表明TEF具有抗炎和抗溃疡作用，部分原因是其抗氧化作用，已知多酚（包括单宁）具有这种作用。
