Kop'eva T N, Voronina L M, Shashev N S, Karabinenko A A
Lab Delo. 1991(4):35-41.
The authors analyze cytologic and bacterioscopic changes in bronchoalveolar washings in 37 patients with acute focal pneumonia on days 4 through 44 of the disease. Bronchoalveolar washings obtained from 11 subjects without pulmonary conditions were examined for control. Immunofluorescent examination of brush biopsy specimens of the bronchial epithelium from 4 patients, taken at the peak of pneumonia, has revealed respiratory viruses antigens. The highest numbers of free bacterial colonies and intracellular bacteria were detectable also at the peak of pneumonia. In contrast to reference specimens, patients' bronchoalveolar washings were characterized by elevated absolute counts of the neutrophils, bronchoepitheliocytes, and destroyed cells during the peak and regress of the disease. During convalescence these cell counts were essentially reducing though persisting significantly elevated as against the control. Absolute counts of alveolar macrophages and lymphocytes in bronchoalveolar washings were virtually unchanged over the course of the disease. The authors claim that the cytologic and bacterioscopic characteristics of bronchoalveolar washings objectively and fully reflect the activity of the inflammatory reaction in the lungs.
作者分析了37例急性局灶性肺炎患者在病程第4天至44天支气管肺泡灌洗的细胞学和细菌学变化。取11名无肺部疾病受试者的支气管肺泡灌洗物作为对照。对4例患者在肺炎高峰期采集的支气管上皮刷检活检标本进行免疫荧光检查，发现了呼吸道病毒抗原。在肺炎高峰期也可检测到最高数量的游离细菌菌落和细胞内细菌。与对照标本相比，患者的支气管肺泡灌洗物在疾病高峰期和消退期的特点是中性粒细胞、支气管上皮细胞和破坏细胞的绝对计数升高。在恢复期，这些细胞计数虽有下降，但与对照组相比仍显著升高。支气管肺泡灌洗物中肺泡巨噬细胞和淋巴细胞的绝对计数在病程中基本未变。作者认为，支气管肺泡灌洗的细胞学和细菌学特征客观而全面地反映了肺部炎症反应的活性。
